A Structural View on Medicinal Chemistry Strategies against Drug Resistance
作者： Stefano Agnello , Michael Brand , Mathieu F. Chellat , Silvia Gazzola , Rainer Riedl
关键词: Anti-Infective Agents 、 Medicine 、 Resistance (ecology) 、 Drug discovery 、 Antifungal drugs 、 Natural phenomenon 、 Intensive care medicine 、 Drug resistance
摘要: The natural phenomenon of drug resistance is a widespread issue that hampers the performance drugs in many major clinical indications. Antibacterial and antifungal are affected, as well compounds for treatment cancer, viral infections, or parasitic diseases. Despite very diverse set biological targets organisms involved development resistance, underlying molecular mechanisms have been identified to understand emergence overcome this detrimental process. Detailed structural information on root causes nowadays frequently available, so next-generation can be designed anticipated suffer less from resistance. This knowledge-based approach essential fighting inevitable occurrence
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