Association of Nonalcoholic Fatty Liver Disease With Osteoporotic Fractures: A Cross-Sectional Retrospective Study of Chinese Individuals.
作者： Yanmao Wang , Gen Wen , Runhua Zhou , Wanrun Zhong , Shengdi Lu
关键词: Retrospective cohort study 、 Odds ratio 、 Nonalcoholic fatty liver disease 、 Internal medicine 、 Medicine 、 Risk factor 、 Logistic regression 、 Dyslipidemia 、 Cross-sectional study 、 Confidence interval
摘要: Objective: Nonalcoholic fatty liver disease (NAFLD) is related to several inflammatory or metabolic diseases. However, findings of previous studies investigating the association between NAFLD and BMD are inconsistent. Only one study reported a potential osteoporotic fracture. This investigated whether in older participants (>55 years) was associated with fracture risk. Materials Methods: cross-sectional, observational included 2,695 (35.7% men, 614 cases NAFLD, 383 fractures). Standardized questionnaires, laboratory tests, physical ultrasonic examinations were completed. Results: After adjusting for various factors including serum triglycerides (TG), high-density cholesterol (HDL-C), low-density lipoprotein (LDL-C), multivariate logistic regression models revealed marginal risk men (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.06-3.27; P = 0.030) but no women (OR, 1.05; CI, 0.74-1.48; 0.800). Further stratified analyses showed significant without high TG, low HDL-C, LDL-C. Conclusions: There Chinese particularly dyslipidemia.
frontiersin.org
sci-hub.se 参考文章(53)
Manuel R. Blum, Douglas C. Bauer, Tinh-Hai Collet, Howard A. Fink, Anne R. Cappola, Bruno R. da Costa, Christina D. Wirth, Robin P. Peeters, Bjørn O. Åsvold, Wendy P. J. den Elzen, Robert N. Luben, Misa Imaizumi, Alexandra P. Bremner, Apostolos Gogakos, Richard Eastell, Patricia M. Kearney, Elsa S. Strotmeyer, Erin R. Wallace, Mari Hoff, Graziano Ceresini, Fernando Rivadeneira, André G. Uitterlinden, David J. Stott, Rudi G. J. Westendorp, Kay-Tee Khaw, Arnuf Langhammer, Luigi Ferrucci, Jacobijn Gussekloo, Graham R. Williams, John P. Walsh, Peter Jüni, Drahomir Aujesky, Nicolas Rodondi, Subclinical thyroid dysfunction and fracture risk: A meta-analysis JAMA. ,vol. 313, pp. 2055- 2065 ,(2015) , 10.1001/JAMA.2015.5161
Seong Hee Ahn, Hyeonmok Kim, Beom-Jun Kim, Seung Hun Lee, Jung-Min Koh, Insulin resistance and composite indices of femoral neck strength in Asians: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) Clinical Endocrinology. ,vol. 84, pp. 185- 193 ,(2016) , 10.1111/CEN.12958
I. R. Reid, M. C. Evans, G. J. Cooper, R. W. Ames, J. Stapleton, Circulating insulin levels are related to bone density in normal postmenopausal women. American Journal of Physiology-endocrinology and Metabolism. ,vol. 265, ,(1993) , 10.1152/AJPENDO.1993.265.4.E655
Doosup Shin, Soyeun Kim, Kyae Hyung Kim, Kiheon Lee, Sang Min Park, Association between insulin resistance and bone mass in men. The Journal of Clinical Endocrinology and Metabolism. ,vol. 99, pp. 988- 995 ,(2014) , 10.1210/JC.2013-3338
Na Kyung Lee, Hideaki Sowa, Eiichi Hinoi, Mathieu Ferron, Jong Deok Ahn, Cyrille Confavreux, Romain Dacquin, Patrick J. Mee, Marc D. McKee, Dae Young Jung, Zhiyou Zhang, Jason K. Kim, Franck Mauvais-Jarvis, Patricia Ducy, Gerard Karsenty, Endocrine Regulation of Energy Metabolism by the Skeleton Cell. ,vol. 130, pp. 456- 469 ,(2007) , 10.1016/J.CELL.2007.05.047
Edward W Gregg, Jane A Cauley, Dana G Seeley, Kristine E Ensrud, Douglas C Bauer, Physical Activity and Osteoporotic Fracture Risk in Older Women Annals of Internal Medicine. ,vol. 129, pp. 81- 88 ,(1998) , 10.7326/0003-4819-129-2-199807150-00002
Gregory R. Mundy, Osteoporosis and inflammation. Nutrition Reviews. ,vol. 65, pp. 147- 151 ,(2007) , 10.1111/J.1753-4887.2007.TB00353.X
Elisabetta Bugianesi, Amalia Gastaldelli, Melania Gaggini, Mariangela Morelli, Emma Buzzigoli, Ralph DeFronzo, Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease Nutrients. ,vol. 5, pp. 1544- 1560 ,(2013) , 10.3390/NU5051544
Jian-Gao Fan, Geoffrey C. Farrell, Epidemiology of non-alcoholic fatty liver disease in China Journal of Hepatology. ,vol. 50, pp. 204- 210 ,(2009) , 10.1016/J.JHEP.2008.10.010
Shinya Ishii, Jane A. Cauley, Carolyn J. Crandall, Preethi Srikanthan, Gail A. Greendale, Mei-Hua Huang, Michelle E. Danielson, Arun S. Karlamangla, Diabetes and femoral neck strength: findings from the Hip Strength Across the Menopausal Transition Study. The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, pp. 190- 197 ,(2012) , 10.1210/JC.2011-1883