The Carcinogenic Activity of Some 5-Nitrofuran Derivatives in the Rat

摘要: Three 5-nitrofuran derivatives showed carcinogenic activity when fed to female Holtzman rats at levels of 0.1 0.3% in a commercial diet for up 44.5 weeks, while 2 other and 5,5-diphenylhydantoin were inactive. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide induced benign malignant tumors the mammary glands, adenomas or adenocarcinomas kidney, intestine, carcinomas external auditory canal. 5-Nitro-2-furaldehyde semicarbazone produced only which histologically benign. Acetone [4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazone multiple squamous papillomas nonglandular forestomach. 5-Nitro-2-furanmethandiol diacetate 1-[(5-nitrofurfurylidene)amino] hydantoin inactive. These compounds tested on hypothesis that moiety might have activity. Since nitrofurans not carcinogenic, however, possibility observed been due hydrazine thiazole moieties also is discussed.