Future prospects and challenges of vaccines against filariasis.

摘要: Filarial infections remain a major public health and socio-economic problem across the tropics, despite considerable effort to reduce disease burden or regionally eliminate infection with mass drug administration programmes. The sustainability of these programmes is now open question owing range issues, not least which emerging evidence for resistance. Vaccination, if developed appropriately, remains most cost-effective means long-term control. rationale feasibility vaccination against filarial parasites including onchocerciasis (river blindness, Onchocerca volvulus) lymphatic filariasis (Wuchereria bancrofti Brugia malayi) founded on from both humans animal models development protective immunity. Nonetheless, enormous challenges need be faced in terms overcoming parasite-induced suppression without inducing pathology as well recognize tackle evolutionary ecological obstacles successful vaccine development. new technological advances addition systems biology approaches offer hope that optimal immune responses can induced will prevent infection, and/or transmission.