Factors Associated With Mortality In Extrapulmonary Tuberculosis Patients At A Teaching Hospital In Ghana

摘要: Objectives : To investigate the clinical manifestations and factors associated with mortality in patients with extrapulmonary tuberculosis (EPTB) at Korle-Bu Teaching Hospital Chest Clinic Accra, Ghana. Design We conducted a retrospective chart review of patients treated for EPTB between January 1, 2009 and December 31, 2011. Patients with a new diagnosis of without concomitant pulmonary disease, aged 18 years or older, who were treated were eligible participation in study. Relevant data abstracted from medical records entered into database. The factors associated examined using bivariate multivariate analysis. Results Of 157 study, most affected age group was 25-34 old (33.1%), 57.3% were male, 71 (55.5%) 128 tested for HIV sero-positive. Overall, 62 (39.5%) died during treatment. Mortality with disseminated TB (AOR 149.85; P < 0.001), meningitis (AOR 79.14; abdominal (AOR 23.59; = 0.011), pleural effusion 12.6; = 0.021) age 1.05; 0.021). Among HIV co-infected patients, early initiation ART reduced mortality rate. Conclusions site key determinant of mortality. Given that death occurs soon after diagnosis, patients suspected meningitis, disseminated, abdominal should be targeted for early treatment to reduce high EPTB mortality our setting. Key words: Extrapulmonary TB, coinfection, Treatment outcomes, Mortality, Adults, Ghana