Stretch induced hyperexcitability of mice callosal pathway

摘要: Memory and learning are thought to result from changes in synaptic strength. Previous studies on physiology brain slices have traditionally been focused biochemical processes. Here, we demonstrate with experiments mouse that central nervous system plasticity is also sensitive mechanical stretch. This important, given the host of clinical conditions involving tension brain, normal role plays development. A novel platform developed investigate neural responses stretching. Flavoprotein autofluoresence (FA) imaging was employed for measuring activity. We observed excitability substantially increases after a small (2.5%) stretch held 10 minutes released. The increase accumulative, i.e. multiple cycles further excitability. analytical tools quantify spatial spread response Results show less stable undergoing stretch-unstretch cycle. FA amplitude activation rate decrease as cases but not electrically enhanced cases. These results collectively physiological range can modulate activities significantly, suggesting events be tool modulation plasticity.