Disulfide-Functionalized Unimolecular Micelles as Selective Redox-Responsive Nanocarriers

摘要: Redox-sensitive hyperbranched dendritic-linear polymers (HBDLPs) were prepared and stabilized individually as unimolecular micelles with diameters in the range 25-40 nm. The high molecular weight (500-950 kDa), core-shell amphiphilic structures synthesized through a combination of self-condensing vinyl copolymerization (SCVCP) atom transfer radical polymerization (ATRP). Cleavable disulfide bonds introduced, either backbone, or pendant groups, core HBDLPs. By triggered reductive degradation, HBDLPs showed up to 7-fold decrease weight, extent degradation was tuned by amount incorporated disulfides. HBDLP disulfide-linked functionalities readily postfunctionalized hydrophobic dye, mimic for drug. An instant release dye observed response environment similar one present intracellularly. proposed strategy shows facile route highly stable micelles, which attractively exhibit redox-responsive cargo properties.