Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases.
作者： Lisa M Ryno , R Luke Wiseman , Jeffery W Kelly
DOI: 10.1016/J.CBPA.2013.04.009
关键词: Protein folding 、 Translational attenuation 、 Proteostasis 、 Homeostasis 、 Biology 、 Signal transduction 、 Cell biology 、 Unfolded protein response 、 Endoplasmic reticulum 、 Protein biosynthesis
摘要: Protein homeostasis (or proteostasis) within the endoplasmic reticulum (ER) is regulated by unfolded protein response (UPR). The UPR consists of three integrated signaling pathways activated accumulation misfolded proteins ER lumen. Activation alters proteostasis through translational attenuation new synthesis and transcriptional remodeling pathways, providing a mechanism to adapt in cellular stress. capacity alter suggests that exogenous manipulation offers therapeutic promise fate pathologic associated with human misfolding diseases. Here, we discuss potential activation treat disease highlight specific small molecule approaches for regulating could be beneficial
elsevier.com
sci-hub.se 参考文章(39)
R. Luke Wiseman, Yuhong Zhang, Kenneth P.K. Lee, Heather P. Harding, Cole M. Haynes, Joshua Price, Frank Sicheri, David Ron, Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. ,vol. 38, pp. 291- 304 ,(2010) , 10.1016/J.MOLCEL.2010.04.001
P. Walter, D. Ron, The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation Science. ,vol. 334, pp. 1081- 1086 ,(2011) , 10.1126/SCIENCE.1209038
Alexei V. Korennykh, Pascal F. Egea, Andrei A. Korostelev, Janet Finer-Moore, Chao Zhang, Kevan M. Shokat, Robert M. Stroud, Peter Walter, The unfolded protein response signals through high-order assembly of Ire1. Nature. ,vol. 457, pp. 687- 693 ,(2009) , 10.1038/NATURE07661
Christopher J. Guerriero, Jeffrey L. Brodsky, The Delicate Balance Between Secreted Protein Folding and Endoplasmic Reticulum-Associated Degradation in Human Physiology Physiological Reviews. ,vol. 92, pp. 537- 576 ,(2012) , 10.1152/PHYSREV.00027.2011
T Kudo, S Kanemoto, H Hara, N Morimoto, T Morihara, R Kimura, T Tabira, K Imaizumi, M Takeda, A molecular chaperone inducer protects neurons from ER stress Cell Death & Differentiation. ,vol. 15, pp. 364- 375 ,(2008) , 10.1038/SJ.CDD.4402276
Wei-Chieh Chiang, Nobuhiko Hiramatsu, Carissa Messah, Heike Kroeger, Jonathan H. Lin, Selective Activation of ATF6 and PERK Endoplasmic Reticulum Stress Signaling Pathways Prevent Mutant Rhodopsin Accumulation Investigative Ophthalmology & Visual Science. ,vol. 53, pp. 7159- 7166 ,(2012) , 10.1167/IOVS.12-10222
Rungtawan Sriburi, Suzanne Jackowski, Kazutoshi Mori, Joseph W. Brewer, XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum Journal of Cell Biology. ,vol. 167, pp. 35- 41 ,(2004) , 10.1083/JCB.200406136
Jun Wu, D. Thomas Rutkowski, Meghan Dubois, Jayanth Swathirajan, Thomas Saunders, Junying Wang, Benbo Song, Grace D.-Y. Yau, Randal J. Kaufman, ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress Developmental Cell. ,vol. 13, pp. 351- 364 ,(2007) , 10.1016/J.DEVCEL.2007.07.005
Tetsuya OKADA, Hiderou YOSHIDA, Rieko AKAZAWA, Manabu NEGISHI, Kazutoshi MORI, Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochemical Journal. ,vol. 366, pp. 585- 594 ,(2002) , 10.1042/BJ20020391
Keisuke Yamamoto, Takashi Sato, Toshie Matsui, Masanori Sato, Tetsuya Okada, Hiderou Yoshida, Akihiro Harada, Kazutoshi Mori, Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 Developmental Cell. ,vol. 13, pp. 365- 376 ,(2007) , 10.1016/J.DEVCEL.2007.07.018