Diagnosis and Management of Fetal Bradyarrhythmias

作者: EDGAR T. JAEGGI , MARK K. FRIEDBERG

DOI: 10.1111/J.1540-8159.2008.00957.X

关键词: Atrioventricular blockGestationCardiac outputPregnancyDexamethasoneMedicineAnesthesiaTransplacentalPersistent Fetal BradycardiaFetus

摘要: Complete atrioventricular block (CAVB) is the most common cause of persistent fetal bradycardia. In presence a structurally normal heart, it develops primarily in anti-Ro and anti-La positive antibody pregnancies after 20 weeks gestation. There significant risk perinatal demise, particularly association with hydrops, poor ventricular function, heart rates < 55 beats/min. Transplacental treatment strategies are aimed at preventing or modulating these factors. Maternal administration dexamethasone to mitigate prevent concomitant myocardial inflammation, combination beta-stimulation for bradycardia beats/min increase cardiac output, has resulted significantly improved neonatal outcomes without reversing CAVB.

参考文章(13)
Edgar T. Jaeggi, Jean-Claude Fouron, Earl D. Silverman, Greg Ryan, Jeffrey Smallhorn, Lisa K. Hornberger, Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease Circulation. ,vol. 110, pp. 1542- 1548 ,(2004) , 10.1161/01.CIR.0000142046.58632.3A
Theresa Menéndez, Stephan Achenbach, Ernst Beinder, Michael Hofbeck, Lutz Klinghammer, Helmut Singer, Werner Moshage, Werner G. Daniel, Usefulness of magnetocardiography for the investigation of fetal arrhythmias The American Journal of Cardiology. ,vol. 88, pp. 334- 336 ,(2001) , 10.1016/S0002-9149(01)01658-7
Myles J.O. Taylor, Mark J. Smith, Matthew Thomas, Andrew R. Green, Floria Cheng, Salome Oseku-Afful, Ling Y. Wee, Nicholas M. Fisk, Helena M. Gardiner, Non-invasive fetal electrocardiography in singleton and multiple pregnancies BJOG: An International Journal of Obstetrics and Gynaecology. ,vol. 110, pp. 668- 678 ,(2003) , 10.1046/J.1471-0528.2003.02005.X
Antonio Brucato, Maria Graziana Astori, Rolando Cimaz, Paola Villa, M Li Destri, Laura Chimini, Roberto Vaccari, Marina Muscarà, Mario Motta, Angela Tincani, Francesca Neri, Stefano Martinelli, None, Normal neuropsychological development in children with congenital complete heart block who may or may not be exposed to high‐dose dexamethasone in utero Annals of the Rheumatic Diseases. ,vol. 65, pp. 1422- 1426 ,(2006) , 10.1136/ARD.2005.049866
A.J.J.T. Rein, C. O’Donnell, T. Geva, A. Nir, Z. Perles, I. Hashimoto, X.-K. Li, D.J. Sahn, Use of Tissue Velocity Imaging in the Diagnosis of Fetal Cardiac Arrhythmias Circulation. ,vol. 106, pp. 1827- 1833 ,(2002) , 10.1161/01.CIR.0000031571.92807.CC
A. M. Groves, L. D. Allan, E. Rosenthal, Outcome of isolated congenital complete heart block diagnosed in utero. Heart. ,vol. 75, pp. 190- 194 ,(1996) , 10.1136/HRT.75.2.190
E. T. Jaeggi, L. K. Hornberger, J. F. Smallhorn, J.-C. Fouron, Prenatal diagnosis of complete atrioventricular block associated with structural heart disease: combined experience of two tertiary care centers and review of the literature. Ultrasound in Obstetrics & Gynecology. ,vol. 26, pp. 16- 21 ,(2005) , 10.1002/UOG.1919
Y. Maeno, N. Rikitake, O. Toyoda, Y. Kiyomatsu, T. Miyake, W. Himeno, A. Hirose, D. Hori, T. Kamura, H. Kato, Prenatal diagnosis of sustained bradycardia with 1 : 1 atrioventricular conduction. Ultrasound in Obstetrics & Gynecology. ,vol. 21, pp. 234- 238 ,(2003) , 10.1002/UOG.71
M. Hofbeck, H. Ulmer, E. Beinder, E. Sieber, H. Singer, Prenatal findings in patients with prolonged QT interval in the neonatal period. Heart. ,vol. 77, pp. 198- 204 ,(1997) , 10.1136/HRT.77.3.198