Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer.

摘要: Treatment of ovarian cancer is challenging due to late stage diagnosis, acquired drug resistance mechanisms, and systemic toxicity chemotherapeutic agents. Combination chemotherapy has the potential enhance treatment efficacy by activation multiple downstream pathways overcome reducing required dosages. Sequence delivery dosing schedule can further efficacy. Formulation combinations into nanoparticles Due their versatility, polymer-based are an especially promising tool for clinical translation combination therapies with tunable schedules. We review polymer nanoparticle (e.g., micelles, dendrimers, lipid nanoparticles) carriers formulated treat cancer. In particular, focus on this platinum taxane agents (commonly used first line treatments cancer) combined other small molecule therapeutic vitro in vivo potency discussed a quantifiable synergistic effects. The effect sequence examined. Computational approaches as predict schedules future design also briefly discussed.