作者: Bruno Di Marco Vieira , Rowan A. Radford , Roger S. Chung , Gilles J. Guillemin , Dean L. Pountney
关键词: Parkinsonism 、 Inclusion bodies 、 Cerebellar ataxia 、 Chemistry 、 Neuroinflammation 、 Astrogliosis 、 Atrophy 、 Neuroscience 、 Microglia 、 Microgliosis
摘要: Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions (GCIs) rich in α-synuclein (α-syn) constitute the hallmark, accompanied by neuronal loss and activation glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation abnormal inclusion bodies induce neuroinflammation which, interestingly, might also favor intracellular aggregates as consequence cytokine release shift pro-inflammatory environment. Here, we critically review relationships between astrocytic microglial MSA explore potential therapeutics target