Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

作者: Bruno Di Marco Vieira , Rowan A. Radford , Roger S. Chung , Gilles J. Guillemin , Dean L. Pountney

DOI: 10.3389/FNCEL.2015.00437

关键词: ParkinsonismInclusion bodiesCerebellar ataxiaChemistryNeuroinflammationAstrogliosisAtrophyNeuroscienceMicrogliaMicrogliosis

摘要: Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting with combinations of autonomic dysfunction, parkinsonism, cerebellar ataxia and/or pyramidal signs. Oligodendroglial cytoplasmic inclusions (GCIs) rich in α-synuclein (α-syn) constitute the hallmark, accompanied by neuronal loss and activation glial cells which indicate neuroinflammation. Recent studies demonstrate that α-syn may be released from degenerating neurons to mediate formation abnormal inclusion bodies induce neuroinflammation which, interestingly, might also favor intracellular aggregates as consequence cytokine release shift pro-inflammatory environment. Here, we critically review relationships between astrocytic microglial MSA explore potential therapeutics target

参考文章(115)
Rowan Radford, Mathew Wong, Dean L. Pountney, Neurodegenerative aspects of multiple system atrophy Springer. pp. 2157- 2180 ,(2014) , 10.1007/978-1-4614-5836-4_110
Stephen D. Skaper, Laura Facci, Massimo Barbierato, Morena Zusso, Giuseppe Bruschetta, Daniela Impellizzeri, Salvatore Cuzzocrea, Pietro Giusti, N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution. Molecular Neurobiology. ,vol. 52, pp. 1034- 1042 ,(2015) , 10.1007/S12035-015-9253-8
Hui-Ming Gao, Bin Liu, Jau-Shyong Hong, Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons The Journal of Neuroscience. ,vol. 23, pp. 6181- 6187 ,(2003) , 10.1523/JNEUROSCI.23-15-06181.2003
Z. Ahmed, Y. T. Asi, A. Sailer, A. J. Lees, H. Houlden, T. Revesz, J. L. Holton, The neuropathology, pathophysiology and genetics of multiple system atrophy Neuropathology and Applied Neurobiology. ,vol. 38, pp. 4- 24 ,(2012) , 10.1111/J.1365-2990.2011.01234.X
Simone Engelender, α-synuclein fate Autophagy. ,vol. 8, pp. 418- 420 ,(2012) , 10.4161/AUTO.19085
Jose L Labandeira-Garcia, Jannette Rodriguez-Pallares, Begoña Villar-Cheda, Ana I Rodríguez-Perez, Pablo Garrido-Gil, Maria J Guerra, None, Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra. Aging and Disease. ,vol. 2, pp. 257- 274 ,(2011)
Lucile Ben Haim, Maria-Angeles Carrillo-de Sauvage, Kelly Ceyzériat, Carole Escartin, Elusive roles for reactive astrocytes in neurodegenerative diseases. Frontiers in Cellular Neuroscience. ,vol. 9, pp. 278- 278 ,(2015) , 10.3389/FNCEL.2015.00278