A synthetic encapsulating emulsifier using complex-forming pentacosadiynoyl cyclosophoraoses (cyclic β-(1, 2)-d-glucan)
作者： Hwanhee Kim , Someshwar D. Dindulkar , Daham Jeong , Seyeon Park , Bong-Hyun Jun
DOI: 10.1016/J.JIEC.2016.08.032
关键词: Molecule 、 Moiety 、 Glucan 、 Sudan III 、 Two-dimensional nuclear magnetic resonance spectroscopy 、 Bioactive molecules 、 Combinatorial chemistry 、 Organic chemistry 、 Chemistry 、 Lipophilicity
摘要: Abstract A new pentacosadiynoyl cyclosophoraose (P-Cys) was synthesized using a biosourced cyclooligosaccharide with intrinsic complexation capacity. NOESY analysis revealed that switchable molecular behavior of moiety attached to P-Cys dependent on the external lipophilicity. Both encapsulation by and emulsification in make it possible finely formulate nanoemulsion state for an hydrophobic guest molecule like Sudan III. Various physicochemical properties emulsions were investigated TEM DLS. The results indicate is useful potential platform encapsulating bioactive molecules cosmetic pharmaceutical applications.
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