Hormone-dependence of experimental mammary tumours.

摘要: The effect of hormones on mammary tumours induced experimentally in animals are revised. It is stated that the tumoural induction and/or growth may depend their concentration and moment, relation to animal exposure carcinogen, which they administered. presently known action mechanisms also indicated, bringing out importance increased level differentiation high estrogen doses induce, as well some effects progesterone pregnancy protection against experimental cancer its promoters. efficacy therapeutic ablative operations--ovariectomy, hypophysectomy adrenalectomy--and additive ones--antihormones--in tumor regression, shown. Finally molecular bases hormonedependence established, while trying provide an integrated concept between: hormones, receptor, factors, oncogens carcinogenesis.