Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis.
作者： Xiaojun Huang , Chaoqun Wang , Jinmin Sun , Jun Luo , Jiangzhou You
DOI: 10.3892/OL.2017.7394
关键词: CagA 、 Tissue microarray 、 Carcinogenesis 、 Oncology 、 Survival rate 、 Biology 、 Cancer 、 Oncogene 、 Internal medicine 、 Molecular medicine 、 Metastasis
摘要: Gastric cancer (GC) is the fourth most common type of malignant tumor worldwide, and causes second highest number cancer-associated mortalities in 2012. tumorigenesis a multistep multifactorial process. In present study, tissue microarray immunohistochemistry analysis were used to detect cytotoxin-associated gene A (CagA), c-Met, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) Beclin-1 expression 121 GC tumors 120 normal gastric tissues. The clinical relevance prognostic implications CagA, PI3K patients analyzed. Furthermore, Cox proportional hazards model was performed indicate independent factors for patients, including various clinicopathological parameters expression. results indicated that CagA-positive H. pylori infection, may have major roles oncogenesis, invasion lymph node metastasis GC. disease-free survival rate negatively associated with c-Met CagA tissues, positively Overall also PI3K, This be efficient biomarkers predicting DFS infection-associated GC, significantly upregulated downregulated. infection therefore signaling pathway suppression autophagy neoplasia,
sci-hub.se 参考文章(26)
Haihui Qin, Qingzeng Sun, Fengfei Zhang, Yang Shen, Yingchun Shi, Rong Wang, Baobiao Zhuo, Yuan Li, Zhengwei Li, PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma Biochemical and Biophysical Research Communications. ,vol. 464, pp. 401- 406 ,(2015) , 10.1016/J.BBRC.2015.06.092
Hideaki Higashi, Kazuyuki Yokoyama, Yumiko Fujii, Shumei Ren, Hitomi Yuasa, Iraj Saadat, Naoko Murata-Kamiya, Takeshi Azuma, Masanori Hatakeyama, EPIYA Motif Is a Membrane-targeting Signal ofHelicobacter pyloriVirulence Factor CagA in Mammalian Cells Journal of Biological Chemistry. ,vol. 280, pp. 23130- 23137 ,(2005) , 10.1074/JBC.M503583200
Yuri Churin, Laila Al-Ghoul, Oliver Kepp, Thomas F. Meyer, Walter Birchmeier, Michael Naumann, Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response Journal of Cell Biology. ,vol. 161, pp. 249- 255 ,(2003) , 10.1083/JCB.200208039
Nadeem Wajih, Jennifer Walter, David C. Sane, Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met) Circulation Research. ,vol. 90, pp. 46- 52 ,(2002) , 10.1161/HH0102.102756
Keizo Taniguchi, Yukata Yonemura, Naomi Nojima, Yasuo Hirono, Sachio Fushida, Takashi Fujimura, Koichi Miwa, Yoshio Endo, Hiroshi Yamamoto, Hideomi Watanabe, The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase-type plasminogen activator receptor Cancer. ,vol. 82, pp. 2112- 2122 ,(1998) , 10.1002/(SICI)1097-0142(19980601)82:11<2112::AID-CNCR5>3.0.CO;2-X
Maria J. Oliveira, Ana C. Costa, Angela M. Costa, Lara Henriques, Gianpaolo Suriano, John C. Atherton, Jose C. Machado, Fatima Carneiro, Raquel Seruca, Marc Mareel, Ancy Leroy, Ceu Figueiredo, Helicobacter pylori Induces Gastric Epithelial Cell Invasion in a c-Met and Type IV Secretion System-dependent Manner Journal of Biological Chemistry. ,vol. 281, pp. 34888- 34896 ,(2006) , 10.1074/JBC.M607067200
YANYAN HU, LI LI, WENBIN YIN, LIN SHEN, BEIAN YOU, HAIQING GAO, Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel. Molecular Medicine Reports. ,vol. 10, pp. 2051- 2058 ,(2014) , 10.3892/MMR.2014.2459
Shun Zhang, Ping Chen, Zuoan Huang, Xiaorong Hu, Mengting Chen, Shanshan Hu, Yixin Hu, Ting Cai, Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a Scientific Reports. ,vol. 5, pp. 9787- 9787 ,(2015) , 10.1038/SREP09787
Guillermo I. Perez-Perez, Martin J. Blaser, Timothy L. Cover, Grant N. Stemmermann, Richard M. Peek, Harry Kleanthous, P. H. Chyou, Abraham Nomura, Infection with Helicobacter pylori Strains Possessing cagA Is Associated with an Increased Risk of Developing Adenocarcinoma of the Stomach Cancer Research. ,vol. 55, pp. 2111- 2115 ,(1995)
Artur Cunha Vasconcelos, Vivian Petersen Wagner, Luise Meurer, Pablo Agustin Vargas, Lélia Batista de Souza, Felipe Paiva Fonseca, Cristiane Helena Squarize, Rogerio Moraes Castilho, Manoela Domingues Martins, None, Immunoprofile of c-MET/PI3K signaling in human salivary gland tumors. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology. ,vol. 120, pp. 238- 247 ,(2015) , 10.1016/J.OOOO.2015.04.003