Molecular and biochemical evidence on the role of zearalenone in rat polycystic ovary
作者： Nakisa Abbasian , Saeideh Momtaz , Maryam Baeeri , Mona Navaei-Nigjeh , Rohollah Hosseini
DOI: 10.1016/J.TOXICON.2018.07.022
关键词: Medicine 、 Luteinizing hormone 、 Internal medicine 、 Hormone 、 Polycystic ovary 、 Endocrinology 、 Atresia 、 Tumor necrosis factor alpha 、 Testosterone 、 Mycotoxin 、 Zearalenone
摘要: Abstract Globally, food and animal feed contamination with mycotoxins is one of the most important challenges affecting human health. Zearalenone a non-steroidal mycotoxin estrogen-like activity that has been reported to induce reproductive dysfunctions including polycystic ovary in women. The aim this study was assess possible impact prolonged low dose zearalenone (0.1 mg/kg b.w.) exposure increase risk developing rats. We found increases plasma insulin, glucose, testosterone, progesterone luteinizing hormone levels, while estradiol level reduced. also incited tumor necrosis factor-α secreted frizzled-related protein-4 expressions. Histological examination showed atresia follicles treated group. It concluded intoxication intensely manipulates hormonal factors gene expressions related rats, thus its progression.
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