Gamma Knife surgery for large vestibular schwannomas: a single-center retrospective case-matched comparison assessing the effect of lesion size.
作者： Brian J. Williams , Zhiyuan Xu , David J. Salvetti , Ian T. McNeill , James Larner
关键词: Surgery 、 Gamma-knife surgery 、 Medicine 、 Nuclear medicine 、 Effective treatment 、 Retrospective cohort study 、 Vestibular Schwannomas 、 Single Center 、 Radiosurgery 、 Progression-free survival 、 Lesion
摘要: Object Gamma Knife surgery (GKS) is a safe and effective treatment for patients with small to moderately sized vestibular schwannomas (VSs). Reports of stereotactic radiosurgery large VSs have demonstrated worse tumor control preservation neurological function. The authors endeavored assess the effect size treated using GKS. Methods This study was retrospective comparison 24 (> 3 cm in maximum diameter) GKS compared 49 (≤ cm) matched age, sex, radiosurgical margin maximal doses, length follow-up, indication. Results Actuarial progression-free survival (PFS) VS cohort 95.2% 81.8% at 5 years, respectively, 97% 90% (p = 0.009). Overall clinical outcome better < 0.001). Patients presenting House-Brackmann Grade I (good facial function) had outcomes pat...
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