Surveillance and Cleavage of Eukaryotic tRNAs

摘要: Beyond their central role in protein synthesis, transfer RNAs (tRNAs) have many other crucial functions. This includes various roles the regulation of gene expression, stress responses, metabolic processes and priming reverse transcription. In RNA world, tRNAs are, with ribosomal RNAs, among most stable molecules. Nevertheless, they are not eternal. As key elements cell function, need to be continuously quality-controlled. Two tRNA surveillance pathways been identified. They act on hypo-modified or mis-processed pre-tRNAs mature lacking modifications. A short overview these two will presented here. Furthermore, while exoribonucleases acting ultimately lead complete degradation, numerous tRNA-derived fragments (tRFs) present within a cell. These cleavage products now potentially emerge as new class small non-coding (sncRNAs) suspected important regulatory The tRFs evolutionarily widespread created by at different positions endonucleases. Here, we review our knowledge biogenesis function organisms.