Autophagy: Regulation and role in development

摘要: Autophagy is an evolutionarily conserved cellular process through which long-lived proteins and damaged organelles are recycled to maintain energy homeostasis. These sequestered into a double-membrane structure, or autophagosome, subsequently fuses with lysosome in order degrade the cargo. Although originally classified as type of programmed cell death, autophagy more widely viewed basic survival mechanism combat environmental stressors. genes were initially identified yeast found be necessary circumvent nutrient stress starvation. Subsequent elucidation mammalian gene counterparts has highlighted importance this normal development. This review provides overview autophagy, types its regulation known impact on development gleaned primarily from murine models.