Favorable long-term effect of a low-fat/high-fiber diet on human blood coagulation and fibrinolysis.
作者： P Marckmann , B Sandström , J Jespersen
关键词: Blood sampling 、 Factor VII 、 Coagulation 、 Fibrinolysis 、 Saturated fat 、 Plasminogen activator 、 Endocrinology 、 Fibrinogen 、 Medicine 、 Internal medicine 、 Blood plasma
摘要: In an 8-month strictly controlled dietary study of 16 healthy young men, the long-term effect a low-fat (26% energy) high-fiber (4.5 g/MJ) diet on cardiovascular risk markers hemostatic system was assessed. Fasting blood sampling performed during 4-week baseline period and then monthly intervention. A matched control group men habitual diets also monitored. Median fibrinolytic activity tissue-type plasminogen activator (t-PA) in plasma significantly elevated (twofold to fourfold) by experimental diet. significant increase systemic euglobulin fraction observed. factor VII coagulant (F VIIc) depressed 5-10% first 2 months last month period. The change did not affect levels fibrinogen, t-PA antigen, or inhibitor type I antigen. conclusion, who were switched from typical Danish high saturated fat low-fat/high-fiber showed permanent biphasic decrease F VIIc. thus had favorable system.
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