Genetic and cell biological aspects of PTEN in prostate cancer
作者： Petra van Duijn
DOI:
关键词: Cancer research 、 PTEN 、 Genetics 、 Prostate cancer 、 Tensin 、 Suppressor 、 Cell 、 Biology 、 Stem cell 、 Carcinogenesis 、 Phosphatase
摘要: textabstractThe dual specific phosphatase PTEN (Phosphatase and TENsin homolog deleted on chromosome 10) is one of the most extensively studied proteins last decade. It was first identified as a tumor suppressor in sporadic cancers frequently altered genes. Its deregulation also implicated several other diseases. In addition, critically important during embryonic development key player maintaining normal stem cell function. Unraveling physiological regulation function will augment our understanding tumorigenesis ultimately lead to novel therapeutic options.
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