IMMUNE RESPONSE DRUG CONJUGATES: CARBON-14 LABELING NECESSITIES

作者: Pramod Singh Khatri

DOI:

关键词: Oncolytic virusProstate cancerClinical trialRadiation therapyImmunologyGenetic enhancementDrugInternal medicineOncologyCancerImmunotherapyMedicine

摘要: Despite recent advances in early detection and treatment, prostate cancer is the most common second leading cause of cancer-related deaths developed countries. Prostate patients having a limited number treatment options such as radiotherapy, cytotoxic chemotherapy etc. Although results all approaches are showing beneficial effects, but without long term survival benefit. A development field named gene therapy comes existence with promise treatment. It an emerging against not only for types cancers. With advancement basic research technology, no doubt it may be best future use genetic engineering clinical trials. In this review we tried to conclude importance novel unique characteristics cure hope management cancer. KEYWORDS: Gene Therapy, Carcinoma Prostate, Transfer, Immunotherapy, Oncolytic Virotherapy.

参考文章(63)
Upneet K. Sokhi, Belal Azab, Siddik Sarkar, Xue-Ning Shen, Paul Dent, Zhao-zhong Su, Devanand Sarkar, Rupesh Dash, David T. Curiel, Igor P. Dmitriev, Paul B. Fisher, Steven Grant, Xiang-Yang Wang, Pier Paolo Claudio, Developing an Effective Gene Therapy for Prostate Cancer: New Technologies with Potential to Translate from the Laboratory into the Clinic Discovery Medicine. ,vol. 11, pp. 46- 56 ,(2011)
A. M. DeMarzo, T. L. DeWeese, B. Mikhak, M. Goemann, Ronald Rodriguez, W. G. Nelson, R. DeJong, J. W. Simons, M. A. Carducci, D. C. Yu, R. Drew, Y. Chen, U. Hamper, S. Piantadosi, H. Van der Poel, S. Li, N. Detorie, D. R. Henderson, T. Haulk, A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Research. ,vol. 61, pp. 7464- 7472 ,(2001)
Hyam I Levitsky, Alan W Partin, Angelo M DeMarzo, Bahar Mikhak, Steven Piantadosi, Marti A Goemann, Christine E Weber, William G Nelson, Fray F Marshall, H. Ballentine B Carter, Lawrence K Cohen, Jonathan W Simons, Michael A Carducci Md, Richard C Mulligan, Ju-Fay Chang, Angelo A. Baccala Jr Md, Michael Lim, Shirley M Clift, Martin G Sanda, Dale G Ando, Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer Cancer Research. ,vol. 59, pp. 5160- 5168 ,(1999)
Svend O. Freytag, Kenneth R. Rogulski, Dell L. Paielli, David H. Kirn, Carla C. Heise, Jeff D. Gilbert, Kang Zhang, Jae Ho Kim, In Vivo Antitumor Activity of ONYX-015 Is Influenced by p53 Status and Is Augmented by Radiotherapy Cancer Research. ,vol. 60, pp. 1193- 1196 ,(2000)
G. Di Lorenzo, S. De Placido, Hormone refractory prostate cancer (HRPC): present and future approaches of therapy. International Journal of Immunopathology and Pharmacology. ,vol. 19, pp. 11- 34 ,(2006) , 10.1177/205873920601900103
Svend O Freytag, Mark Khil, Hans Stricker, James Peabody, Mani Menon, Mariza DePeralta-Venturina, Daniel Nafziger, Jan Pegg, Dell Paielli, Steve Brown, Ken Barton, Mei Lu, Estuardo Aguilar-Cordova, Jae Ho Kim, None, Phase I Study of Replication-competent Adenovirus-mediated Double Suicide Gene Therapy for the Treatment of Locally Recurrent Prostate Cancer Cancer Research. ,vol. 62, pp. 4968- 4976 ,(2002)
Leisha A. Emens, Elizabeth M. Jaffee, Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer Research. ,vol. 65, pp. 8059- 8064 ,(2005) , 10.1158/0008-5472.CAN-05-1797
M. Liu, B. Acres, J.-M. Balloul, N. Bizouarne, S. Paul, P. Slos, P. Squiban, Gene-based vaccines and immunotherapeutics Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 14567- 14571 ,(2004) , 10.1073/PNAS.0404845101
Tony Reid, Robert Warren, David Kirn, Intravascular adenoviral agents in cancer patients: Lessons from clinical trials Cancer Gene Therapy. ,vol. 9, pp. 979- 986 ,(2002) , 10.1038/SJ.CGT.7700539
James R. Herman, Howard L. Adler, Estuardo Aguilar-Cordova, Augusto Rojas-Martinez, Savio Woo, Terry L. Timme, Thomas M. Wheeler, Timothy C. Thompson, Peter T. Scardino, In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial. Human Gene Therapy. ,vol. 10, pp. 1239- 1249 ,(1999) , 10.1089/10430349950018229