Sorafenib therapy in patients with advanced hepatocellular carcinoma in advanced liver cirrhosis.

作者: Kerstin Schütte , Lars Zimmermann , Jan Bornschein , Antal Csepregi , Ricarda Rühl

DOI: 10.1159/000320377

关键词: Hepatocellular carcinomaGastroenterologySorafenibInternal medicineIn patientCirrhosisMedicine

摘要: Background and Aim: Sorafenib has become the treatment standard for patients with advanced hepatocellular carcinoma (HCC). It is not clear whether liver funct

参考文章(26)
Philip Johnson, Role of alpha-fetoprotein in the diagnosis and management of hepatocellular carcinoma. Journal of Gastroenterology and Hepatology. ,vol. 14, ,(1999) , 10.1046/J.1440-1746.1999.01873.X
Yeo Hyeon Hwang, Jong Young Choi, Soyoun Kim, Eun Sun Chung, Taeuk Kim, Sang Seok Koh, Bogman Lee, Si Hyun Bae, Jin Kim, Young Min Park, Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatology Research. ,vol. 29, pp. 113- 121 ,(2004) , 10.1016/J.HEPRES.2004.02.009
Josep M Llovet, Sergio Ricci, Vincenzo Mazzaferro, Philip Hilgard, Edward Gane, Jean-Frédéric Blanc, Andre Cosme De Oliveira, Armando Santoro, Jean-Luc Raoul, Alejandro Forner, Myron Schwartz, Camillo Porta, Stefan Zeuzem, Luigi Bolondi, Tim F Greten, Peter R Galle, Jean-François Seitz, Ivan Borbath, Dieter Häussinger, Tom Giannaris, Minghua Shan, Marius Moscovici, Dimitris Voliotis, Jordi Bruix, None, Sorafenib in Advanced Hepatocellular Carcinoma The New England Journal of Medicine. ,vol. 359, pp. 378- 390 ,(2008) , 10.1056/NEJMOA0708857
Jordi Bruix, Loreto Boix, Margarita Sala, Josep M Llovet, Focus on hepatocellular carcinoma Cancer Cell. ,vol. 5, pp. 215- 219 ,(2004) , 10.1016/S1535-6108(04)00058-3
A Tannapfel, F Sommerer, M Benicke, A Katalinic, D Uhlmann, H Witzigmann, J Hauss, C Wittekind, Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma Gut. ,vol. 52, pp. 706- 712 ,(2003) , 10.1136/GUT.52.5.706
P. M. LOPEZ, A. VILLANUEVA, J. M. LLOVET, Systematic review: evidence‐based management of hepatocellular carcinoma – an updated analysis of randomized controlled trials Alimentary Pharmacology & Therapeutics. ,vol. 23, pp. 1535- 1547 ,(2006) , 10.1111/J.1365-2036.2006.02932.X
Ann-Lii Cheng, Yoon-Koo Kang, Zhendong Chen, Chao-Jung Tsao, Shukui Qin, Jun Suk Kim, Rongcheng Luo, Jifeng Feng, Shenglong Ye, Tsai-Sheng Yang, Jianming Xu, Yan Sun, Houjie Liang, Jiwei Liu, Jiejun Wang, Won Young Tak, Hongming Pan, Karin Burock, Jessie Zou, Dimitris Voliotis, Zhongzhen Guan, None, Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncology. ,vol. 10, pp. 25- 34 ,(2009) , 10.1016/S1470-2045(08)70285-7
Hashem B. El-Serag, Jorge A. Marrero, Lenhard Rudolph, K. Rajender Reddy, Diagnosis and Treatment of Hepatocellular Carcinoma Gastroenterology. ,vol. 134, pp. 1752- 1763 ,(2008) , 10.1053/J.GASTRO.2008.02.090
Giuseppe Cabibbo, Federica Latteri, Michela Antonucci, Antonio Craxì, Multimodal approaches to the treatment of hepatocellular carcinoma. Nature Clinical Practice Gastroenterology & Hepatology. ,vol. 6, pp. 159- 169 ,(2009) , 10.1038/NCPGASTHEP1357
Marcus Alexander Wörns, Arndt Weinmann, Kerstin Pfingst, Carla Schulte-Sasse, Claudia-Martina Messow, Henning Schulze-Bergkamen, Andreas Teufel, Marcus Schuchmann, Stephan Kanzler, Christoph Düber, Gerd Otto, Peter Robert Galle, Safety and efficacy of sorafenib in patients with advanced hepatocellular carcinoma in consideration of concomitant stage of liver cirrhosis. Journal of Clinical Gastroenterology. ,vol. 43, pp. 489- 495 ,(2009) , 10.1097/MCG.0B013E31818DDFC6