Comparative studies of coordination properties of puromycin and puromycin aminonucleoside towards copper(II) ions.
作者： Ariel Mucha , Wojciech Bal , Małgorzata Jeżowska-Bojczuk
DOI: 10.1016/J.JINORGBIO.2007.06.031
关键词: Copper 、 Crystallography 、 Chemistry 、 Protonation 、 Puromycin 、 Circular dichroism 、 Moiety 、 Steric effects 、 Electron paramagnetic resonance 、 Molecule
摘要: Protonation equilibria of puromycin (PM) and aminonucleoside (PAN) their coordination by copper(II) ion were studied in solution potentiometry, electronic absorption spectroscopy (UV–Vis), circular dichroism (CD), electron paramagnetic resonance (EPR) mass spectrometry. For four mononuclear complexes found, with stoichiometries Cu(PM)2+, CuH−1(PM)+, CuH−2(PM) CuH−3(PM)–. In each them the Cu(II) was bound peptidic-like manner, differences are a consequence subsequent deprotonations sugar C2’-OH group coordinated water molecule. The mode for aminosugar-like. Two dimeric complexes, Cu2H-1(PAN)22+ Cu2H-2(PAN)2+, one monomeric CuH−2(PAN)2 found. N6,N6-dimethyladenine moiety PAN not involved process due to steric hindrance.
elsevier.com
sci-hub.se 参考文章(47)
Andrew M. Nemeth, G. de la Haba, The Effect of 5-Fluorouracil on the Developmental and Adaptive Formation of Tryptophan Pyrrolase Journal of Biological Chemistry. ,vol. 237, pp. 1190- 1193 ,(1962) , 10.1016/S0021-9258(18)60306-0
Emil Kmetec, Ann Tirpack, Metabolism of puromycin aminonucleoside in the rat. Formation of nucleotide derivatives. Biochemical Pharmacology. ,vol. 19, pp. 1493- 1500 ,(1970) , 10.1016/0006-2952(70)90065-1
Jorma Arpalahti, Eeva Ottoila, Complexing of 3d transition metal ions with 9-substituted purines. III. The effect of polar substituents on binding sites and stabilities Inorganica Chimica Acta. ,vol. 107, pp. 105- 110 ,(1985) , 10.1016/S0020-1693(00)82282-3
Piotr Kaczmarek, Małgorzata Jeżowska-Bojczuk, Wojciech Bal, Kazimierz S. Kasprzak, Determination of the stability constants and oxidation susceptibility of nickel(II) complexes with 2'-deoxyguanosine 5'-triphosphate and L-histidine. Journal of Inorganic Biochemistry. ,vol. 99, pp. 737- 746 ,(2005) , 10.1016/J.JINORGBIO.2004.12.006
William L. Jorgensen, Jayaraman Chandrasekhar, Jeffry D. Madura, Roger W. Impey, Michael L. Klein, Comparison of simple potential functions for simulating liquid water The Journal of Chemical Physics. ,vol. 79, pp. 926- 935 ,(1983) , 10.1063/1.445869
M. B. Yarmolinsky, G. L. D. L. Haba, INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEIN. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 45, pp. 1721- 1729 ,(1959) , 10.1073/PNAS.45.12.1721
Dorota Wrześniok, Arkadiusz Surażyński, Ewa Karna, Ewa Buszman, Jerzy Pałka, Melanin counter act puromycin-induced inhibition of collagen and DNA biosynthesis in human skin fibroblasts. Life Sciences. ,vol. 77, pp. 528- 538 ,(2005) , 10.1016/J.LFS.2004.10.070
Donald E. Newlin, Margaret A. Pellack, Robert Nakon, Kinetics and mechanism of tetradentate nickel(II) chelate and metal nitrilotriacetate promoted hydrolysis of methyl glycinate: an isokinetic relationship. Journal of the American Chemical Society. ,vol. 99, pp. 1078- 1082 ,(1977) , 10.1021/JA00446A017
Enric Casassas, Anna Izquierdo-Ridorsa, Rom� Tauler, Electron paramagnetic resonance and visible spectroscopic studies of mixed-ligand complexes of copper(II) ion, salicylate ion, and a nitrogen base in aqueous solution Journal of The Chemical Society-dalton Transactions. pp. 2341- 2345 ,(1990) , 10.1039/DT9900002341
D. Nathans, PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 51, pp. 585- 592 ,(1964) , 10.1073/PNAS.51.4.585