Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression.
作者： Zachary M. Bush , Janina A. Longtine , Tracy Cunningham , David Schiff , John A. Jane
DOI: 10.1210/JC.2010-0441
关键词: Medicine 、 Context (language use) 、 Endocrinology 、 Pituitary neoplasm 、 Pituitary tumors 、 O-6-methylguanine-DNA methyltransferase 、 Pituitary carcinoma 、 DNA methylation 、 Temozolomide 、 Internal medicine 、 Malignant transformation
摘要: Context: The typically indolent behavior of pituitary tumors is juxtaposed with high rates tumor cell invasion into adjacent dural structures, and occasional aggressive behavior. Although clinically significant malignant transformation remain uncommon, there are limited treatment options available for the management these tumors. Recently, case reports have described efficacy temozolomide Design: Seven patients been treated temozolomide. We compared O6-methylguanine methyltransferase (MGMT) promoter methylation MGMT expression in 14 surgical specimens from seven correlated molecular features clinical response to Results: Significant regression was seen two (29%), a 20% reduction volume subsequent stable size noted one patient, arrest growth occurred three patients, progr...
oup.com
endojournals.org参考文章(42)
R.N. Clayton, W.E. Farrell, Pituitary tumour clonality revisited. Frontiers of Hormone Research. ,vol. 32, pp. 186- 204 ,(2004) , 10.1159/000079045
Su-ming Hsu, Laurence Raine, Herbert Fanger, The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. American Journal of Clinical Pathology. ,vol. 75, pp. 816- 821 ,(1981) , 10.1093/AJCP/75.6.816
Markus Christmann, Georg Nagel, Sigrid Horn, Ulrike Krahn, Dorothee Wiewrodt, Clemens Sommer, Bernd Kaina, MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma. International Journal of Cancer. ,vol. 127, pp. 2106- 2118 ,(2010) , 10.1002/IJC.25229
Björn P. Meij, Maria-Beatriz S. Lopes, Dilantha B. Ellegala, Tord D. Alden, Edward R. Laws, The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery. Journal of Neurosurgery. ,vol. 96, pp. 195- 208 ,(2002) , 10.3171/JNS.2002.96.2.0195
Joseph L. Fleiss, Measuring nominal scale agreement among many raters. Psychological Bulletin. ,vol. 76, pp. 378- 382 ,(1971) , 10.1037/H0031619
Terri J Jackson, Jude L Michel, Rosemary Roberts, Jennie Shepheard, Diana Cheng, Julie Rust, Catherine Perry, Development of a validation algorithm for 'present on admission' flagging BMC Medical Informatics and Decision Making. ,vol. 9, pp. 48- 48 ,(2009) , 10.1186/1472-6947-9-48
Ying-Wen Su, Ming-Chih Chang, Ming-Fu Chiang, Ruey-Kuen Hsieh, Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma. Journal of Neuro-oncology. ,vol. 71, pp. 315- 318 ,(2005) , 10.1007/S11060-004-2028-0
Lisa M. Neff, Michelle Weil, Alan Cole, Thomas R. Hedges, William Shucart, Donald Lawrence, Jay-Jiguang Zhu, Arthur S. Tischler, Ronald M. Lechan, Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists. Pituitary. ,vol. 10, pp. 81- 86 ,(2007) , 10.1007/S11102-007-0014-1
Peter J. Pernicone, Bernd W. Scheithauer, Thomas J. Sebo, Kalman T. Kovacs, Eva Horvath, William F. Young, Ricardo V. Lloyd, Dudley H. Davis, Barton L. Guthrie, William C. Schoene, Pituitary carcinoma: a clinicopathologic study of 15 cases. Cancer. ,vol. 79, pp. 804- 812 ,(1997) , 10.1002/(SICI)1097-0142(19970215)79:4<804::AID-CNCR18>3.0.CO;2-3
Ferah Yildiz, Faruk Zorlu, Tomris Erbaş, Lale Atahan, Radiotherapy in the management of giant pituitary adenomas. Radiotherapy and Oncology. ,vol. 52, pp. 233- 237 ,(1999) , 10.1016/S0167-8140(99)00098-5