Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light
作者： Carmen Navarro-Ranninger , Patrick J Bednarski , Jaroslav Malina , Adoración G Quiroga , None
DOI: 10.1016/J.JINORGBIO.2015.07.008
关键词: Nanotechnology 、 Biological activity 、 Platinum 、 Reactivity (chemistry) 、 Uva light 、 Cytotoxicity 、 Chemistry 、 In vitro 、 DNA 、 Stereochemistry 、 Antitumor activity
摘要: Trans diiodido platinum(II) complexes bearing the same as well different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important models already been demonstrated. Herein we described interaction of such compounds ct-DNA, supercoiled linearized plasmid DNA 5-GMP. Interestingly, UV irradiation these results in an increase reactivity towards 5-GMP model systems. Additionally, trans-Pt(II) human cancer cells is noticeably increased when treatment combined for 90min UVA-irradiation. With this work provide evidence that trans can be activated by UV-light over relatively short times.
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