Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes.
作者： Gyeoung-Jin Kang , Sang-Chul Han , Jong-Woo Ock , Hee-Kyoung Kang , Eun-Sook Yoo
DOI: 10.4062/BIOMOLTHER.2013.001
关键词: Immunology 、 Pharmacology 、 HaCaT 、 Citrus unshiu 、 CCL17 、 Quercetin 、 Quercetagetin 、 Chemokine 、 Anti-inflammatory 、 Medicine 、 CCL22
摘要: Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these are changed during maturation and immature is known to larger amounts than mature. Chemokines significant mediators for cell migration, while thymus activation-regulated chemokine (TARC/CCL17) macrophage-derived (MDC/CCL22) well as typical inflammatory chemokines in atopic dermatitis (AD), a pruritic chronic skin disease. We reported recently EtOH extract unshiu inhibits TARC MDC production. Therefore, we investigated activity contained on levels. As result, among flavonoids, quercetagetin has stronger inhibitory effects protein mRNA expression other flavonoids. Quercetagetin particularly better level quercetin. In HPLC analysis, standard peak matches peaks C. unshiu. This suggests an anti-inflammatory component
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