Fabrication and characterization of PNA–DNA hybrid nanostructures

摘要: Although the distinct properties and synthesis methodology of peptide nucleic acid (PNA) molecules have been established by extensive studies, construction an artificial nanostructure made from PNA has examined in only a few reports. Here we study feasibility constructing PNA–DNA hybrid nanostructures conventional free solution annealing substrate assisted growth methods. For annealing, introduced 2-step procedure to mitigate self-aggregation formation stable structures. Atomic force microscopy images revealed smaller than normal DNA Raman band intensities gradually decreased as strands were replaced possibly due fast binding structural stress between DNA.