Cooperating transcription factors mediate the function of estrogen receptor
作者： Elisa Fiorito , Madhumohan R. Katika , Antoni Hurtado
DOI: 10.1007/S00412-012-0392-7
关键词: Estrogen receptor 、 Cell biology 、 Estrogen receptor binding 、 DNA-binding protein 、 Promoter 、 Internal medicine 、 Estrogen receptor beta 、 Transcription factor 、 Estrogen receptor alpha 、 Biology 、 Androgen receptor 、 Endocrinology
摘要: Estrogen receptor (ER) is a hormone-regulated transcription factor that controls cell division and differentiation in the ovary, breast, uterus. The expression of ER common feature majority breast cancers, which used as therapeutic target. Recent genetic studies have shown binding occurs regions distant to promoters estrogen target genes. These also demonstrated accompanied with other factors, regulate function response anti-estrogen therapies. In this review, we explain how these factors influence interaction chromatin their cooperation for transcriptional activity. Moreover, describe dictates Finally, discuss cytoplasmatic signaling pathways may modulate its cooperating factors.
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