Synthesis of Fluoroalkyl Pyrazoles from In‐Situ‐Generated C2F5CHN2 and Electron‐Deficient Alkenes
作者： Pavel K. Mykhailiuk , Aleksandr Yu. Ishchenko , Viatcheslav Stepanenko , Janine Cossy
关键词: Electron 、 Fluorine 、 Organic chemistry 、 In situ 、 Pyrazole 、 Aromatization 、 Cycloaddition 、 Chemistry
摘要: C2F5-substituted pyrazolines were synthesized by [3+2]-cycloaddition between in-situ-generated C2F5CHN2 and electron-deficient alkenes. The addition of DBU led to the elimination HF give CF3CHF-substituted pyrazoles. Depending on structure pyrazolines, different products obtained.
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