Intracranial Hypertension and Sumatriptan Efficacy in a Case of Chronic Paroxysmal Hemicrania Which Became Bilateral. (The Mechanism ofIndomethacin in CPH.)

摘要: SYNOPSIS A female patient is described who had a four year long period of unilateral chronic paroxysmalhemicrania (CPH) which then became bilateral. For some years before the CPH started she suffered fromperiods about one month with hemicrania without nerve involvement. She also fromchronic fatigue, back pain, arthralgia, vertigo, constipation and spontaneous ecchymoses. Bloodtests showed leukocytosis, low serum iron, signs inflammation in electrophoresisduring five was studied. attacks could be provoked by breathing 6% carbon dioxide inair. Lumbar cerebrospinal fluid pressure pathologically increased (30 cm water). The attacksdecreased during indomethacin treatment but 275 mg needed for satisfactory control attacks,i.e., more than 150 which, according to criteria CPH, should absolutely effective.Sumatriptan found suppress as well indomethacin. Due these findings isconsidered another manifestation venous vasculitis. beneficiary mechanism indomethacinin considered due partly its anti-inflammatory effects reduction theintracranial blood flow.