Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds
作者： Erika Tassano , Angela Alama , Andrea Basso , Giancarlo Dondo , Andrea Galatini
关键词: Triazole 、 Ether 、 Chemistry 、 Cytotoxicity 、 Polyphenol 、 Organic chemistry 、 Hydroxytyrosol
摘要: Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether triazole linkers were employed. A small library compounds prepared, stressing step economy operational simplicity. Some these substances proven to have activity equal or superior the parent hydroxytyrosol in radical scavenging assays as well cytotoxicity tests against tumour cells.
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