Toxoplasma gondii: the growth characteristics of three virulent strains
作者： Peter J Appleford , Judith E Smith
DOI: 10.1016/S0001-706X(97)00656-6
关键词: Microbiology 、 Phenotype 、 Toxoplasma gondii 、 Doubling time 、 Biology 、 Virulence 、 In vitro growth 、 Virology 、 Parasite hosting 、 Strain (chemistry) 、 Parasitology 、 Infectious Diseases 、 General Medicine
摘要: We have studied the phenotype of three mouse virulent strains Toxoplasma gondii (RH, Martin and ENT), monitoring cellular factors which may relate to virulence. There was variation between these in separate criteria: invasion, growth tachyzoite‐bradyzoite interconversion. The ENT strain exhibited consistently higher invasion rates, a shorter doubling time lower frequency bradyzoite production than or RH strains. In addition rate, there were also differences morphology parasites, with exhibiting highly synchronous division giving rise characteristic rosettes. produced bradyzoites at and, culture, parasites often seen tight clusters, reminiscent early tissue cysts. These phenotypic variations amongst mouse-virulent parasite imply underlying genetic within group. © 1997 Elsevier Science B.V.
elsevier.com
researchgate.net 
sci-hub.se 参考文章(32)
N. Cristina, B. Oury, P. Ambroise-Thomas, F. Santoro, Restriction-fragment-length polymorphisms among Toxoplasma gondii strains. Parasitology Research. ,vol. 77, pp. 266- 268 ,(1991) , 10.1007/BF00930870
K H Ely, J R Mineo, I A Khan, R McLeod, L H Kasper, J Smith, D Mack, Antibodies to Toxoplasma gondii major surface protein (SAG-1, P30) inhibit infection of host cells and are produced in murine intestine after peroral infection. Journal of Immunology. ,vol. 150, pp. 3951- 3964 ,(1993)
E Skamene, C R Brown, R McLeod, D G Mack, P B Eisenhauer, Genetic regulation of early survival and cyst number after peroral Toxoplasma gondii infection of A x B/B x A recombinant inbred and B10 congenic mice. Journal of Immunology. ,vol. 143, pp. 3031- 3034 ,(1989)
Zhi-Gang Guo, Alan M. Johnson, Genetic comparison of Neospora caninum with Toxoplasma and Sarcocystis by random amplified polymorphic DNA-polymerase chain reaction. Parasitology Research. ,vol. 81, pp. 365- 370 ,(1995) , 10.1007/BF00931495
W Bohne, J Heesemann, U Gross, Induction of bradyzoite-specific Toxoplasma gondii antigens in gamma interferon-treated mouse macrophages. Infection and Immunity. ,vol. 61, pp. 1141- 1145 ,(1993) , 10.1128/IAI.61.3.1141-1145.1993
S Tomavo, B Fortier, M Soete, C Ansel, D Camus, J F Dubremetz, Characterization of bradyzoite-specific antigens of Toxoplasma gondii. Infection and Immunity. ,vol. 59, pp. 3750- 3753 ,(1991) , 10.1128/IAI.59.10.3750-3753.1991
F G Araujo, D M Williams, F C Grumet, J S Remington, Strain-dependent differences in murine susceptibility to toxoplasma. Infection and Immunity. ,vol. 13, pp. 1528- 1530 ,(1976) , 10.1128/IAI.13.5.1528-1530.1976
Wolfgang Bohne, Jurgen Heesemann, Uwe Gross, Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens : a possible role for nitric oxide in triggering stage conversion Infection and Immunity. ,vol. 62, pp. 1761- 1767 ,(1994) , 10.1128/IAI.62.5.1761-1767.1994
Kim Luton, Michelle Gleeson, Alan M. Johnson, rRNA gene sequence heterogeneity among Toxoplasma gondii strains. Parasitology Research. ,vol. 81, pp. 310- 315 ,(1995) , 10.1007/BF00931536
Jane Grimwood, Judith E. Smith, Toxoplasma gondii: The role of a 30-kDa surface protein in host cell invasion Experimental Parasitology. ,vol. 74, pp. 106- 111 ,(1992) , 10.1016/0014-4894(92)90144-Y