The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon.
作者： L Cohen , I Sekler , M Hershfinkel
关键词: Cell biology 、 PI3K/AKT/mTOR pathway 、 Tight junction 、 Gene silencing 、 Protein kinase B 、 Intestinal mucosa 、 Occludin 、 Cellular differentiation 、 Intestinal epithelium 、 Biology
摘要: … Zn 2+ -dependent signaling and regulating the proliferation and … Altogether, our results indicate that ZnR/GPR39 has a dual … in extracellular Zn 2+ and major intracellular signaling …
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