PAPEL INMUNOMODULADOR DE LAS DIETAS LIPÍDICAS EN UN MODELO MURINO INMUNOSUPRIMIDO E INFECTADO CON LISTERIA MONOCYTOGENES

摘要: Introduction: Dietary fatty acids immunomodulatory capacity in immunosuppression conditions may differ according to the type of acid present diet. Objective: To analyze effect different types dietary lipids on immune resistance immunosuppressed and immunocompetent animals, against experimental infection with a virulent strain Listeria monocytogenes. Methods: Balb/c mice were divided into four groups, their immunosuppressive treatment: control (PBS), cyclophosphamide (CPA), GK 1.5 RB6-8C5. Each group was subdivided groups lipid diet used which: control, corn oil 5% (BG); olive 20% (AO); fish (AP) sunflower (AG). The animals fed for month before treatment subsequently infected L. Results: We show increases number viable bacteria spleen liver, low survival rates all also PBS AP. Furthermore, lymphocyte proliferation observed, AO treated CPA. Discussion: AP produces significant decrease host situations immunosuppression. On contrary, AG diets major efficiency elimination monocytogenes immunological advantages mice. Treatment RB6-8C5, reduction studied, which leads us establish that granulocytes play key role infection.