Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum
作者： Hidekazu Takahashi , Hideshi Ishii , Naohiro Nishida , Ichiro Takemasa , Tsunekazu Mizushima
DOI: 10.1245/S10434-010-1373-9
关键词: Medicine 、 Wnt signaling pathway 、 Lymphatic metastasis 、 Cancer stem cell 、 Rectum 、 Surgical oncology 、 Pathology 、 Host interface 、 LGR5 、 Receptor
摘要: … that the Wnt targets, genes LGR5 and c-MYC, are co-activated in CRC and are associated with reciprocal activation of p21CIP1/WAF1/CDKN1A, suggesting that Wnt oncogenic signals …
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