Reviewing the Clinical Implications of Treating Narcolepsy as an Autoimmune Disorder

摘要: Narcolepsy type 1 (NT1) is a lifelong sleep disorder, primarily characterized clinically by excessive daytime sleepiness and cataplexy pathologically the loss of hypocretinergic neurons in lateral hypothalamus. Despite being rare NT1-related burden for patients society relevant due to early onset chronic nature this condition. Although etiology narcolepsy still unknown, mounting evidence supports central role autoimmunity. To date, no cure available disorder current treatment symptomatic. Based on hypothesis autoimmune disease, immunotherapy could possibly represent valid therapeutic option. However, contrasting limited results have been provided so far. This review discusses supporting use narcolepsy, outcomes obtained far, issues future directions.