Design choices for next-generation neurotechnology can impact motion artifact in electrophysiological and fast-scan cyclic voltammetry measurements

摘要: Implantable devices to measure neurochemical or electrical activity from the brain are mainstays of neuroscience research and have become increasingly utilized as enabling components clinical therapies. In order increase number recording channels on these while minimizing immune response, flexible electrodes under 10 µm in diameter been proposed ideal next-generation neural interfaces. However, representation motion artifact during electrophysiological recordings using ultra-small, remains unexplored. this short communication, we characterize generated by movement 7 carbon fiber fast-scan cyclic voltammetry (FSCV) measurements electroactive neurochemicals. Through vitro vivo experiments, demonstrate that induced can be problematic distinguish characteristic signals associated with recorded action potentials measurements. These results underscore new electrode materials paradigms alter common sources therefore must carefully characterized.