Triple-Negative Breast Cancer and Obesity in a Rural Appalachian Population

摘要: Background: Our objective was to determine the clinicopathologic features of triple-negative (estrogen receptor, progesterone and human epidermal growth factor-2 receptor negative) breast cancer their relationship obesity in women drawn from a population with one highest rates United States. Methods: This retrospective study involved 620 White patients invasive West Virginia. Hospital tumor registry, charts, pathology records provided age at diagnosis, histologic type, size, nodal status, status. Body mass index calculated value ≥30 considered indicative obesity. Results: Triple-negative tumors occurred 117 (18.9%) patients, most often association ductal carcinomas. Patients were younger than those other types, 44.5% 26.7%, respectively, being diagnosed <50 years ( P = 0.0004). The larger 0.0003), notably women, but small (<2.0 cm) more accompanied by lymph node metastases. Obesity present 49.6% only 35.8% non-triple-negative 0.0098). Lymph metastases frequently associated T2 obese 0.032) regardless status. Conclusions: cancers within White, socioeconomically deprived, later stage obesity, which itself has been poor prognosis cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3319–24)