Toxoplasma gondii glycosylphosphatidylinositols up-regulate major histocompatibility complex (MHC) molecule expression on primary murine macrophages.

摘要: Toxoplasma gondii is an obligatory intracellular parasite able to block the IFN-γ-induced up-regulation of major histocompatibility complex (MHC) class I and II molecules. This facilitates parasite-mediated evasion T-cell responses. Glycosylphosphatidylinositols (GPIs) are involved in pathogenicity protozoan parasites we investigated if GPIs responsible for inhibition MHC expression on macrophages. In contrast blockade observed cells infected with viable tachyzoites, T. up-regulated molecules surface both unstimulated IFN-γ-stimulated primary murine effect was correlated ability increase antigen presentation CD8+ lymphocytes. did not activate STAT1, one factors transcription genes. However, GPI-induced abrogated by SN50, a specific NF-KB inhibitor. Up-regulation m...