Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China.

摘要: Salmonella enterica remains one of the leading causes foodborne bacterial disease. Retail meat is a major source human salmonellosis. However, comparative genomic analyses S. isolates from retail different sources in China are lacking. A total 341 strains were isolated sixteen districts Beijing, China, at three time points (January 1st, May and October 1st) 2017. Comparative genomics was performed to investigate genetic diversity, virulence antimicrobial resistance gene (ARG) profiles these isolates. The most common serotype Enteritidis (203/341, 59.5%), which dominated among during year. Laboratory retesting confirmed accuracy serotyping results predicted by In Silico Typing Resource (SISTR) (96.5%). pangenome contained 13,931 genes, core genome 3,635 genes. Higher phage 118970 sal3 (219/341, 64.2%) Gifsy-2 (206/341, 60.4%) prevalence contributed diversity accessory especially those with unknown functions. IncFII(S), IncX1, IncFIB(S) plasmid replicons more horizontally acquired foreign profile showed fewer genes associated type III secretion systems certain chicken. 88 ARGs found Three beta-lactamases, namely, blaCTX-M-55 (n = 15), blaCTX-M-14 11), blaCTX-M-65 prevalent meats. emergence qnrE1 blaCTX-M-123 indicated potential increase After prohibition colistin four positive for mcr-1.1 mcr-9, respectively. Thus, we explored evolution features meats China. diverse compromise food security clinical threat.