Alteration of cell cycle progression by Sindbis virus infection.

作者: Ruirong Yi , Kengo Saito , Naohisa Isegawa , Hiroshi Shirasawa

DOI: 10.1016/J.BBRC.2015.04.148

关键词: Cyclin ESindbis virusVero cellCyclin ACyclin BVirologyHeLaCell cycleBiologyViral replication

摘要: We examined the impact of Sindbis virus (SINV) infection on cell cycle progression in a cancer line, HeLa, and non-cancerous Vero. Cell analyses showed that SINV is able to alter both HeLa Vero cells, but differently, especially during early stage infection. affected expression several regulators (CDK4, CDK6, cyclin E, p21, A B) cells caused accumulate S phase Monitoring replication expressing indicators revealed which infected G1 preferred proliferate S/G2 phase, average time interval for viral was significantly shorter than phase.

参考文章(29)
Stevan R. Emmett, Brian Dove, Laura Mahoney, Torsten Wurm, Julian A. Hiscox, The cell cycle and virus infection. Methods of Molecular Biology. ,vol. 296, pp. 197- 218 ,(2005) , 10.1385/1-59259-857-9:197
Anne Op De Beeck, Perrine Caillet-Fauquet, Viruses and the cell cycle Progress in Cell Cycle Research. ,vol. 3, pp. 1- 19 ,(1997) , 10.1007/978-1-4615-5371-7_1
Y. Gu, J. Rosenblatt, D.O. Morgan, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. The EMBO Journal. ,vol. 11, pp. 3995- 4005 ,(1992) , 10.1002/J.1460-2075.1992.TB05493.X
Yan Zeng, Kristi Chrispell Forbes, Zhiqi Wu, Sergio Moreno, Helen Piwnica-Worms, Tamar Enoch, Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1 Nature. ,vol. 395, pp. 507- 510 ,(1998) , 10.1038/26766
S Ou, J H Strauss, K S Wang, R J Kuhn, E G Strauss, High-affinity laminin receptor is a receptor for Sindbis virus in mammalian cells. Journal of Virology. ,vol. 66, pp. 4992- 5001 ,(1992) , 10.1128/JVI.66.8.4992-5001.1992
D Resnitzky, M Gossen, H Bujard, S I Reed, Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Molecular and Cellular Biology. ,vol. 14, pp. 1669- 1679 ,(1994) , 10.1128/MCB.14.3.1669
Asako Sakaue-Sawano, Hiroshi Kurokawa, Toshifumi Morimura, Aki Hanyu, Hiroshi Hama, Hatsuki Osawa, Saori Kashiwagi, Kiyoko Fukami, Takaki Miyata, Hiroyuki Miyoshi, Takeshi Imamura, Masaharu Ogawa, Hisao Masai, Atsushi Miyawaki, Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression Cell. ,vol. 132, pp. 487- 498 ,(2008) , 10.1016/J.CELL.2007.12.033
Richard A. Woo, Randy Y.C. Poon, Cyclin-dependent kinases and S phase control in mammalian cells. Cell Cycle. ,vol. 2, pp. 316- 324 ,(2003) , 10.4161/CC.2.4.468
WALID AL-SALEH, PHILIPPE DELVENNE, FRÉDÉRIC A. VAN DEN BRULE, SYLVIE MENARD, JACQUES BONIVER, VINCENT CASTRONOVO, Expression of the 67 kD laminin receptor in human cervical preneoplastic and neoplastic squamous epithelial lesions : An immunohistochemical study The Journal of Pathology. ,vol. 181, pp. 287- 293 ,(1997) , 10.1002/(SICI)1096-9896(199703)181:3<287::AID-PATH762>3.0.CO;2-W