The collision-induced dissociations of deprotonated amides in the gas phase
作者： Mark J. Raftery , John H. Bowie
DOI: 10.1016/0168-1176(88)83013-1
关键词: Chemistry 、 Nitrogen 、 Deprotonation 、 Turn (biochemistry) 、 Gas phase 、 Ion 、 Stereochemistry 、 Proton 、 Medicinal chemistry 、 Elimination reaction
摘要: Abstract The characteristic collision-induced fragmentations of deprotonated unsubstituted and N-substituted amides are reported. Deprotonation occurs at nitrogen except for N,N-di-substituted amides. Fragmentations four types, viz. (a) loss a radical to form stabilized anion, (b) direct formation an anion complex which may then undergo competing reactions, e.g. deprotonation, S N 2 or elimination reactions involving the incipient (c) initial proton transfer new in turn fragments through complexes [as (b), above], (d) involve skeletal rearrangement.
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