The incidence of nosocomial infection in patients receiving total parenteral nutrition

摘要: Although attempts at intravenous alimentation with protein hydrolysates were reported as early 19391, and catheters in the superior vena cava being used for by 19482, little attention was paid to potential infection hazards of this therapy during three decades which it developed. Following initial reports Dudrick, Wilmore their colleagues 1968 that total parenteral nutrition (TPN) could be employed safely long-term apparently normal growth, development positive nitrogen balance3’4, technique widely. A review published TPN from years 1969 1970 indicates many centres experiencing septicaemia rates 14–23 %5–8, one study a rate 93 %9. It not until 1972 when Curry Quie experience reporting combined bacterial fungal 27 % patients receiving TPN10 full significance infectious complications appreciated. The gravity situation emphasized year later Heird his colleagues11 summarized paediatric 37% rate. By 1972, therefore, widely recognized major complication TPN12.