Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair.

作者: Huimei Yu , Yijing Su , Jaehoon Shin , Chun Zhong , Junjie U Guo

DOI: 10.1038/NN.4008

关键词: Cell biologyHomeostatic plasticityCellular neuroscienceSynaptic plasticitySynaptic scalingDNA demethylationBiologyMetaplasticitySynaptic fatigueNeuroscienceNonsynaptic plasticity

摘要: Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation…

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