Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

摘要: The unusual ability of cerium oxide to cleave phosphoester bonds under relatively mild (ambient) conditions was demonstrated using thiamine pyrophosphate (TPP) and nicotinamide adenine dinucleotide (NAD) as model compounds. This phosphatase-mimetic can be exploited in biology or medicine, e.g., for protein design; however, it represents a potential threat vital systems living organisms, such the phosphate backbone DNA RNA. promote cleavage bridging group NAD molecule examined first time; shown that products differ markedly from commonly observed enzymatic non-enzymatic hydrolysis NAD. is highly specific oxide; not comparable extent with any other tested metal oxides (La2O3, Nd2O3, Pr6O11, TiO2, manganese several iron oxides). stems unique properties cations may related measurable and, some extent, adjustable characteristics, crystallinity, surface area, Ce3+/Ce4+ ratio content functional groups. in-house prepared nanocrystalline exhibited higher than commercial nanoceria. interactions nanoparticles TPP were also aid molecular dynamics simulations.