17α-Hydroxyprogesterone caproate versus intravaginal progesterone in IVF–embryo transfer cycles: a prospective randomized study
作者： Vittorio Unfer , Maria Luisa Casini , Loredana Costabile , Sandro Gerli , Domenico Baldini
DOI: 10.1016/S1472-6483(10)62104-9
关键词: Randomized controlled trial 、 Luteal phase 、 Embryo transfer 、 Prospective cohort study 、 Obstetrics 、 Gynecology 、 Pregnancy 、 Luteal support 、 Miscarriage 、 Pregnancy rate 、 Medicine
摘要: One of the main issues in management IVF and embryo transfer techniques is to ensure adequate concentrations progesterone. The aim this prospective, randomized study was compare effectiveness 17α-hydroxyprogesterone caproate (17-HPC) administered intramuscularly intra-vaginal progesterone gel luteal phase support patients undergoing IVF–embryo cycles. A total 320 were randomly treated with either 17-HPC (341 mg i.m. every 3 days) or vaginal (90 daily). inclusion criteria use gonadotrophin-releasing hormone down-regulation age <40 years. outcome both groups evaluated for implantation rate, biochemical pregnancy, clinical miscarriage, ongoing pregnancy rate. results showed that conferred more benefit cycles compared progesterone, as demonstrated by most parameters considered. data days appears be effective providing comparison
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