Reduced relative risk of fractures among users of lithium.

摘要: Lithium has been shown to inhibit bone resorption and interact with Wnt signaling, potentially pointing anabolic properties. We, therefore, studied the effects of lithium on fracture risk using a case–control study design. Cases were all subjects including children any sustained during year 2000 (n = 124,655). For each case, three controls 373,962) matched according age gender was randomly drawn from background population. Adjustments made for use other psychotropic drugs (neuroleptics, antidepressants, anxiolytics/sedatives), psychiatric disease (manic depressive states, schizophrenia, psychoses), confounders. The effect dose examined by stratifying cumulated (DDD, defined daily dose). In crude analysis, there decreasing relative increasing accumulated lithium. After adjustment drug use, decreased (odds ratio [OR] 0.74, 95% confidence interval [CI] 0.60–0.92 250–849 DDD, OR 0.67, CI 0.55–0.81 ≥ 850 DDD lithium). Colles’ fractures spine fractures, significant decrease seen (OR 0.57, 0.35–0.94 0.32, 0.11–0.95 fractures). hip nonsignificant trend toward seen; however, without dose-response relationship. Adjustment further confounders did not change results. treatment associated at