Effects of pinacidil upon penile erectile tissue, in vitro and in vivo.

摘要: The effect of pinacidil, a new antihypertensive vasodilator, was studied in vitro upon human and porcine Corpus cavernosum vivo simian cavernosum. In vitro, pinacidil incubation (10(-5)-10(-3) M) found to induce concentration-dependent inhibition the tissue response norepinephrine (NE) high potassium (K+). Likewise concentration-related relaxation tissue, precontracted with either NE or K+, seen using 10(-5)-10(-3) M. Depending on concentration applied, spontaneous activity as well tone amplitude contractions were reduced until total obtained 10(-3) vivo, 5 mg 0.3 ml solution injected intracavernosally 17 monkeys. Sixteen monkeys developed tumescence 10, rigidity penis well. Only one showed decrease systemic blood pressure. Pinacidil might be clinical interest an agent facilitating erection when given intravernosally.