Assessment of Homocysteine

摘要: Patients with the inborn error homocystinuria have extremely high levels of total plasma homocysteine (tHcy). Deficiency enzyme cystathionine s- synthase (CS) is most common cause, but other enzymic defects been described in a minority these patients. Notably, all forms homocystinuria, irrespective defect, are associated incidence cardiovascular disease, which often occurs early adolescence and even childhood [57]. The vascular disease patients led to Hcy theory atherosclerosis, states that moderate elevation tHcy risk factor for general population [53,54]. During last 20 years, more than 25 retrospective two prospective studies totaling 4000 provided ample evidence atherosclerotic occlusive coronary, cerebrovascular, peripheral beds, as well extracranial carotid vessels [16]. A relation between elevated venous thrombosis has demonstraded some [10, 25, 26] not [20].