Weekly gemcitabine and 24-hour infusional 5-fluorouracil in advanced pancreatic cancer: a phase I-II study.

作者: C. Barone , A. Cassano , D.C. Corsi , C. Pozzo , R. Longo

DOI: 10.1159/000067775

关键词: OncologyChemotherapyFluorouracilMedicineGemcitabinePancreatic diseaseThymidylate synthaseAntimetaboliteInternal medicinePhase i iiPancreatic cancerSurgery

摘要: Objective: In this phase I–II study we explored the potential of combination weekly gemcitabine (GEM) and 24-hour continuous infusion 5-fluorouracil (5-FU) in order to det

参考文章(21)
W. Plunkett, S. Chubb, A. Sen, Yi-Zheng Xu, L. W. Hertel, V. Heinemann, G. B. Grindey, Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Molecular Pharmacology. ,vol. 38, pp. 567- 572 ,(1990)
C H Köhne, P Schöffski, H Wilke, C Käufer, R Andreesen, U Ohl, U Klaasen, M Westerhausen, W Hiddemann, G Schott, A Harstick, J Bade, A Horster, U Schubert, H Hecker, B Dörken, H J Schmoll, Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer. Journal of Clinical Oncology. ,vol. 16, pp. 418- 426 ,(1998) , 10.1200/JCO.1998.16.2.418
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff, R Nelson, F A Dorr, C D Stephens, D D Von Hoff, Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of Clinical Oncology. ,vol. 15, pp. 2403- 2413 ,(1997) , 10.1200/JCO.1997.15.6.2403
Manuel Hidalgo, Daniel Castellano, Luis Paz-Ares, Cristina Gravalos, Maite Diaz-Puente, Ricardo Hitt, Silvia Alonso, Hernan Cortes-Funes, None, Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. Journal of Clinical Oncology. ,vol. 17, pp. 585- 592 ,(1999) , 10.1200/JCO.1999.17.2.585
S. L. Parker, T. Tong, S. Bolden, P. A. Wingo, Cancer statistics, 1997 CA: A Cancer Journal for Clinicians. ,vol. 47, pp. 5- 27 ,(1997) , 10.3322/CANJCLIN.47.1.5
Jordan D. Berlin, Sudeshna Adak, David J. Vaughn, David Flinker, Lawrence Blaszkowsky, Jules E. Harris, A.B. Al Bowen Benson III, A Phase II Study of Gemcitabine and 5-Fluorouracil in Metastatic Pancreatic Cancer: An Eastern Cooperative Oncology Group Study (E3296) Oncology. ,vol. 58, pp. 215- 218 ,(2000) , 10.1159/000012103
S Cascinu, R R Silva, S Barni, R Labianca, L Frontini, E Piazza, G Pancera, P Giordani, L Giuliodori, M A Pessi, V Fusco, G Luporini, R Cellerino, G Catalano, A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). British Journal of Cancer. ,vol. 80, pp. 1595- 1598 ,(1999) , 10.1038/SJ.BJC.6690568
J Carmichael, U Fink, RC Russell, MF Spittle, AL Harris, G Spiessi, J Blatter, Phase II study of gemcitabine in patients with advanced pancreatic cancer. British Journal of Cancer. ,vol. 73, pp. 101- 105 ,(1996) , 10.1038/BJC.1996.18
Helmut Oettle, Uwe Pelzer, Kathrin Mochmuth, Thomas Diebold, Jan Langrehr, Christian A Schmidt, Michael Arning, Thomas J Vogl, Peter Neuhaus, Dieter Huhn, Hanno Riess, Phase I trial of gemcitabine (Gemzar), 24 h infusion 5-fluorouracil and folinic acid in patients with inoperable pancreatic cancer. Anti-Cancer Drugs. ,vol. 10, pp. 699- 704 ,(1999) , 10.1097/00001813-199909000-00002